Журнал «Медицина неотложных состояний» Том 18, №1, 2022

Розвиток анестезіології на початку ХХІ століття характеризується тенденцією до обмеження використання опіоїдів під час як анестезії (низькоопіоїдна та безопіоїдна анестезія), так і післяопераційного знеболювання (мультимодальне знеболювання). Одним із найбільш поширених напрямків зменшення споживання опіоїдів є використання нестероїдних протизапальних засобів. Застосування внутрішньовенної форми добре відомого представника цієї групи препаратів — ібупрофену відкриває нові можливості лікування болю в різних галузях хірургії, анестезіології та інтенсивної терапії. Низка досліджень, результати яких проаналізовані в даному літературному огляді, ґрунтовно доводить, що використання ібупрофену в дозі 800 мг внутрішньовенно дозволяє забезпечити краще післяопераційне знеболювання та зменшення потреби в опіоїдних анальгетиках порівняно з плацебо та таким компаратором, як ацетамінофен. Також ібупрофен для внутрішньовенного введення продемонстрував кращі антипіретичні властивості порівняно з ацетамінофеном при лікуванні лихоманки в госпіталізованих пацієнтів дитячого віку.

The development of anesthesiology during the early XXI century is characterized by a tendency to limit the use of opioids during anesthesia (low-opioid and non-opioid anesthesia) and postoperative analgesia. One of the most common ways to reduce opioid usage is to use nonsteroidal anti-inflammatory drugs. A well-known representative of this drugs ibuprofen opens new opportunities for the treatment of pain in various fields of surgery, anesthesiology, and intensive care. Some studies, which results are analyzed in this literature review, thoroughly prove that the use of ibuprofen at a dose of 800 mg intravenously provides better postoperative analgesia and reduces the need for opioid analgesics compared with placebo and comparators such as acetaminophen. Ibuprofen for intravenous administration also showed better antipyretic properties compared to acetaminophen in the treatment of fever in hospitalized pediatric patients.

біль; анестезія; аналгезія; ібупрофен

pain; anesthesia; analgesia; ibuprofen; review

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