Международный неврологический журнал Том 18, №4, 2022
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Концепція імунопатогенезу енцефалопатії у дітей з розладами спектра аутизму, асоційованими з генетичним дефіцитом фолатного циклу, та потенційні терапевтичні напрямки
Авторы: Мальцев Д.В., Натрус Л.В.
Національний медичний університет імені О.О. Богомольця, м. Київ, Україна
Рубрики: Неврология
Разделы: Справочник специалиста
Версия для печати
Резюме
Аналітичний огляд підсумовує результати власних досліджень у поєднанні із прогресивними поглядами сучасних наукових шкіл щодо актуальної проблеми у світі — діагностики і лікування дітей із розладами спектра аутизму. Отримані дані дозволили сформулювати наукову концепцію імунопатогенезу енцефалопатії у дітей, яка описує найбільш ймовірний сценарій патологічних подій, починаючи з появи патогенних поліморфних замін нуклеотидів у геномі плода і закінчуючи розвитком клінічних симптомів нейропсихіатричних порушень у дитини. Висунення такої концепції відкриває шлях до розробки алгоритму лікування дітей з розладами спектра аутизму, який раніше не був доступним.
The analytical review summarizes the results of our own researches in combination with the progressive views of modern scientific schools on the current problem in the world — the diagnosis and treatment of children with autism spectrum disorders. The obtained data allowed to formulate a scientific concept of encephalopathy immunopathogenesis in children, which describes the most likely scenario of pathological events, starting with the appearance of pathogenic polymorphic nucleotide substitutions in the fetal genome and ending with the development of clinical symptoms of neuropsychiatric disorders in a child. Advancing such a concept paves the way for the development of an algorithm for the treatment of children with autism spectrum disorders, which was not previously available.
Ключевые слова
фолатний цикл, гіпергомоцистеїнемія, поліморфізми, імунодефіцит, енцефалопатія, нейрозапалення, імунотерапія
folate cycle; hyperhomocysteinemia; polymorphisms; immunodeficiency; encephalopathy; neuroinflammation; immunotherapy
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