Журнал «Практична онкологія» Том 6, №2, 2023
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Профілактика та лікування периферичної нейропатії, індукованої хіміотерапією (огляд літератури)
Автори: Ганноцька А.Ю. (1), Зотов О.С. (2)
(1) — The complex oncology center, Masaryk hospital, Ústí nad Labem, Czech Republic
(2) — Національний медичний університет імені О.О. Богомольця, м. Київ, Україна
Рубрики: Онкологія
Розділи: Довідник фахівця
Версія для друку
Периферична нейропатія (ПН), спричинена хіміотерапією, є поширеним побічним ефектом терапії раку, який може мати глибокий вплив на якість життя та виживання. Частота виникнення ПН залежить від хіміотерапевтичного засобу, дози та тривалості впливу. Найчастіше засобами, що індукують ПН, є препарати платини, особливо цисплатин і оксаліплатин, таксани та алкалоїди барвінку. Завдяки успіхам протипухлинної терапії очікується, що кількість вилікуваних пацієнтів зростатиме. Отже, тривала нейротоксичність є важливою проблемою для осіб, що отримували таке лікування, особливо з приводу раку молочної залози та/або товстої кишки. Крім того, периферична нейропатія, індукована хіміотерапією, може негативно впливати на результати лікування через вимушену зміну дози та/або передчасне припинення лікування. Однак, незважаючи на значну поширеність, ПН часто діагностується і лікується незадовільно. У цьому огляді буде розглянуто існуючі методи профілактики та лікування периферичної нейропатії, індукованої хіміопрепаратами.
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer therapy that can have a profound impact on quality of life and survival. The frequency of CIPN depends on the chemotherapeutic agent, dose, and duration of exposure. The agents that most often cause peripheral neuropathy are the platinum drugs, especially cisplatin and oxaliplatin, taxanes and vinca alkaloids. Thanks to advances in anticancer treatment, the number of cancer survivors is expected to increase. Thus, long-term neurotoxicity is a significant concern for individuals undergoing such treatment, especially those who received therapy for breast and/or colon cancer. In addition, chemotherapy-induced peripheral neuropathy may adversely affect treatment outcomes due to forced dose changes and/or premature discontinuation of treatment. However, despite its high prevalence, CIPN often remains an underdiagnosed and undertreated phenomenon. This review will address current methods for the prevention and treatment of chemotherapy-induced peripheral neuropathy.
периферична нейропатія; кріотерапія; компресійна терапія; дулоксетин; габапентиноїди; акупунктура
peripheral neuropathy; cryotherapy; compression therapy; duloxetine; gabapentinoids; acupuncture
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