Международный эндокринологический журнал 5 (45) 2012
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Which antithyroid drug regimen in paediatric Graves’ disease?
Авторы: Schenk D., Donaldson M., Cheetham T.
Рубрики: Эндокринология
Разделы: Справочник специалиста
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Thyrotoxicosis is uncommon in childhood and adolescence with a UK incidence of 1 per 100,000 (0–15 years). Patients are usually treated with a dose titration (DT) regimen or a block and replace (BR) approach using carbimazole (methimazole is not available in the UK). Propylthiouracil should generally be avoided in the young because of the risk of hepatic dysfunction. In DT the quantity of ATD is adjusted with a view to normalising thyroid hormone production. With the block and replace (BR) regimen, thyroid hormone production is prevented completely by ATD with thyroxine then added in a «replacement» dose.
Clinical Endocrinology. — July 2012